Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ
Identifieur interne : 000776 ( Main/Exploration ); précédent : 000775; suivant : 000777Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ
Auteurs : Ahmed A. Al-Qahtani [Arabie saoudite] ; Konstantina Lyroni [Grèce] ; Marina Aznaourova [Grèce] ; Melpomeni Tseliou [Grèce] ; Mashael R. Al-Anazi [Arabie saoudite] ; Mohammed N. Al-Ahdal [Arabie saoudite] ; Saad Alkahtani [Arabie saoudite] ; George Sourvinos [Grèce] ; Christos Tsatsanis [Grèce]Source :
- Oncotarget [ 1949-2553 ] ; 2017.
Descripteurs français
- KwdFr :
- Activation des macrophages (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Facteur de nécrose tumorale alpha (métabolisme), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Inhibiteurs de la dipeptidyl-peptidase IV (pharmacologie), Interactions hôte-pathogène, Interférence par ARN, Interleukin-1 Receptor-Associated Kinases (génétique), Interleukin-1 Receptor-Associated Kinases (métabolisme), Interleukine-10 (métabolisme), Interleukine-6 (métabolisme), Macrophages (), Macrophages (enzymologie), Macrophages (immunologie), Macrophages (virologie), Récepteur PPAR gamma (génétique), Récepteur PPAR gamma (métabolisme), Transduction du signal, Transfection.
- MESH :
- enzymologie : Macrophages.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4, Glycoprotéine de spicule des coronavirus, Interleukin-1 Receptor-Associated Kinases, Récepteur PPAR gamma.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Macrophages.
- métabolisme : Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4, Facteur de nécrose tumorale alpha, Glycoprotéine de spicule des coronavirus, Interleukin-1 Receptor-Associated Kinases, Interleukine-10, Interleukine-6, Récepteur PPAR gamma.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- pharmacologie : Inhibiteurs de la dipeptidyl-peptidase IV.
- virologie : Macrophages.
- Activation des macrophages, Humains, Interactions hôte-pathogène, Interférence par ARN, Macrophages, Transduction du signal, Transfection.
English descriptors
- KwdEn :
- Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Dipeptidyl-Peptidase IV Inhibitors (pharmacology), Host-Pathogen Interactions, Humans, Interleukin-1 Receptor-Associated Kinases (genetics), Interleukin-1 Receptor-Associated Kinases (metabolism), Interleukin-10 (metabolism), Interleukin-6 (metabolism), Macrophage Activation (drug effects), Macrophages (drug effects), Macrophages (enzymology), Macrophages (immunology), Macrophages (virology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (metabolism), Middle East Respiratory Syndrome Coronavirus (pathogenicity), PPAR gamma (genetics), PPAR gamma (metabolism), RNA Interference, Signal Transduction, Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism), THP-1 Cells, Transfection, Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4, Interleukin-1 Receptor-Associated Kinases, PPAR gamma, Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Interleukin-1 Receptor-Associated Kinases, Interleukin-10, Interleukin-6, PPAR gamma, Spike Glycoprotein, Coronavirus, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Dipeptidyl-Peptidase IV Inhibitors.
- drug effects : Macrophage Activation, Macrophages.
- enzymology : Macrophages.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Macrophages, Middle East Respiratory Syndrome Coronavirus.
- metabolism : Middle East Respiratory Syndrome Coronavirus.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- virology : Macrophages.
- Host-Pathogen Interactions, Humans, RNA Interference, Signal Transduction, THP-1 Cells, Transfection.
Abstract
Middle East Respiratory Syndrome Corona Virus (MERS-CoV) is transmitted
Url:
DOI: 10.18632/oncotarget.14754
PubMed: 28118607
PubMed Central: 5354714
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000658
- to stream Pmc, to step Curation: 000658
- to stream Pmc, to step Checkpoint: 000192
- to stream PubMed, to step Corpus: 000615
- to stream PubMed, to step Curation: 000615
- to stream PubMed, to step Checkpoint: 000610
- to stream Ncbi, to step Merge: 000603
- to stream Ncbi, to step Curation: 000603
- to stream Ncbi, to step Checkpoint: 000603
- to stream Main, to step Merge: 000778
- to stream Main, to step Curation: 000776
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses <italic>via</italic> DPP4-mediated induction of IRAK-M and PPARγ</title><author><name sortKey="Al Qahtani, Ahmed A" sort="Al Qahtani, Ahmed A" uniqKey="Al Qahtani A" first="Ahmed A." last="Al-Qahtani">Ahmed A. Al-Qahtani</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea><wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Lyroni, Konstantina" sort="Lyroni, Konstantina" uniqKey="Lyroni K" first="Konstantina" last="Lyroni">Konstantina Lyroni</name><affiliation wicri:level="1"><nlm:aff id="A3"> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Aznaourova, Marina" sort="Aznaourova, Marina" uniqKey="Aznaourova M" first="Marina" last="Aznaourova">Marina Aznaourova</name><affiliation wicri:level="1"><nlm:aff id="A3"> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Tseliou, Melpomeni" sort="Tseliou, Melpomeni" uniqKey="Tseliou M" first="Melpomeni" last="Tseliou">Melpomeni Tseliou</name><affiliation wicri:level="1"><nlm:aff id="A4"> Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Al Anazi, Mashael R" sort="Al Anazi, Mashael R" uniqKey="Al Anazi M" first="Mashael R." last="Al-Anazi">Mashael R. Al-Anazi</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea><wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N." last="Al-Ahdal">Mohammed N. Al-Ahdal</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea><wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alkahtani, Saad" sort="Alkahtani, Saad" uniqKey="Alkahtani S" first="Saad" last="Alkahtani">Saad Alkahtani</name><affiliation wicri:level="1"><nlm:aff id="A5"> Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Zoology Department, College of Science, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sourvinos, George" sort="Sourvinos, George" uniqKey="Sourvinos G" first="George" last="Sourvinos">George Sourvinos</name><affiliation wicri:level="1"><nlm:aff id="A4"> Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Tsatsanis, Christos" sort="Tsatsanis, Christos" uniqKey="Tsatsanis C" first="Christos" last="Tsatsanis">Christos Tsatsanis</name><affiliation wicri:level="1"><nlm:aff id="A3"> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28118607</idno><idno type="pmc">5354714</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354714</idno><idno type="RBID">PMC:5354714</idno><idno type="doi">10.18632/oncotarget.14754</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000658</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000658</idno><idno type="wicri:Area/Pmc/Curation">000658</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000658</idno><idno type="wicri:Area/Pmc/Checkpoint">000192</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000192</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000615</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000615</idno><idno type="wicri:Area/PubMed/Curation">000615</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000615</idno><idno type="wicri:Area/PubMed/Checkpoint">000610</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000610</idno><idno type="wicri:Area/Ncbi/Merge">000603</idno><idno type="wicri:Area/Ncbi/Curation">000603</idno><idno type="wicri:Area/Ncbi/Checkpoint">000603</idno><idno type="wicri:Area/Main/Merge">000778</idno><idno type="wicri:Area/Main/Curation">000776</idno><idno type="wicri:Area/Main/Exploration">000776</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses <italic>via</italic> DPP4-mediated induction of IRAK-M and PPARγ</title><author><name sortKey="Al Qahtani, Ahmed A" sort="Al Qahtani, Ahmed A" uniqKey="Al Qahtani A" first="Ahmed A." last="Al-Qahtani">Ahmed A. Al-Qahtani</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea><wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Lyroni, Konstantina" sort="Lyroni, Konstantina" uniqKey="Lyroni K" first="Konstantina" last="Lyroni">Konstantina Lyroni</name><affiliation wicri:level="1"><nlm:aff id="A3"> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Aznaourova, Marina" sort="Aznaourova, Marina" uniqKey="Aznaourova M" first="Marina" last="Aznaourova">Marina Aznaourova</name><affiliation wicri:level="1"><nlm:aff id="A3"> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Tseliou, Melpomeni" sort="Tseliou, Melpomeni" uniqKey="Tseliou M" first="Melpomeni" last="Tseliou">Melpomeni Tseliou</name><affiliation wicri:level="1"><nlm:aff id="A4"> Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Al Anazi, Mashael R" sort="Al Anazi, Mashael R" uniqKey="Al Anazi M" first="Mashael R." last="Al-Anazi">Mashael R. Al-Anazi</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea><wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N." last="Al-Ahdal">Mohammed N. Al-Ahdal</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea><wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alkahtani, Saad" sort="Alkahtani, Saad" uniqKey="Alkahtani S" first="Saad" last="Alkahtani">Saad Alkahtani</name><affiliation wicri:level="1"><nlm:aff id="A5"> Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Zoology Department, College of Science, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sourvinos, George" sort="Sourvinos, George" uniqKey="Sourvinos G" first="George" last="Sourvinos">George Sourvinos</name><affiliation wicri:level="1"><nlm:aff id="A4"> Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Tsatsanis, Christos" sort="Tsatsanis, Christos" uniqKey="Tsatsanis C" first="Christos" last="Tsatsanis">Christos Tsatsanis</name><affiliation wicri:level="1"><nlm:aff id="A3"> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Dipeptidyl-Peptidase IV Inhibitors (pharmacology)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Interleukin-1 Receptor-Associated Kinases (genetics)</term><term>Interleukin-1 Receptor-Associated Kinases (metabolism)</term><term>Interleukin-10 (metabolism)</term><term>Interleukin-6 (metabolism)</term><term>Macrophage Activation (drug effects)</term><term>Macrophages (drug effects)</term><term>Macrophages (enzymology)</term><term>Macrophages (immunology)</term><term>Macrophages (virology)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Middle East Respiratory Syndrome Coronavirus (metabolism)</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>PPAR gamma (genetics)</term><term>PPAR gamma (metabolism)</term><term>RNA Interference</term><term>Signal Transduction</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>THP-1 Cells</term><term>Transfection</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des macrophages ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Facteur de nécrose tumorale alpha (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Humains</term><term>Inhibiteurs de la dipeptidyl-peptidase IV (pharmacologie)</term><term>Interactions hôte-pathogène</term><term>Interférence par ARN</term><term>Interleukin-1 Receptor-Associated Kinases (génétique)</term><term>Interleukin-1 Receptor-Associated Kinases (métabolisme)</term><term>Interleukine-10 (métabolisme)</term><term>Interleukine-6 (métabolisme)</term><term>Macrophages ()</term><term>Macrophages (enzymologie)</term><term>Macrophages (immunologie)</term><term>Macrophages (virologie)</term><term>Récepteur PPAR gamma (génétique)</term><term>Récepteur PPAR gamma (métabolisme)</term><term>Transduction du signal</term><term>Transfection</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Interleukin-1 Receptor-Associated Kinases</term><term>PPAR gamma</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Interleukin-1 Receptor-Associated Kinases</term><term>Interleukin-10</term><term>Interleukin-6</term><term>PPAR gamma</term><term>Spike Glycoprotein, Coronavirus</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dipeptidyl-Peptidase IV Inhibitors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophage Activation</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Dipeptidyl peptidase 4</term><term>Glycoprotéine de spicule des coronavirus</term><term>Interleukin-1 Receptor-Associated Kinases</term><term>Récepteur PPAR gamma</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Macrophages</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Dipeptidyl peptidase 4</term><term>Facteur de nécrose tumorale alpha</term><term>Glycoprotéine de spicule des coronavirus</term><term>Interleukin-1 Receptor-Associated Kinases</term><term>Interleukine-10</term><term>Interleukine-6</term><term>Récepteur PPAR gamma</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Inhibiteurs de la dipeptidyl-peptidase IV</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Host-Pathogen Interactions</term><term>Humans</term><term>RNA Interference</term><term>Signal Transduction</term><term>THP-1 Cells</term><term>Transfection</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des macrophages</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Interférence par ARN</term><term>Macrophages</term><term>Transduction du signal</term><term>Transfection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East Respiratory Syndrome Corona Virus (MERS-CoV) is transmitted <italic>via</italic> the respiratory tract and causes severe Acute Respiratory Distress Syndrome by infecting lung epithelial cells and macrophages. Macrophages can readily recognize the virus and eliminate it. MERS-CoV infects cells <italic>via</italic> its Spike (S) glycoprotein that binds on Dipeptidyl-Peptidase 4 (DPP4) receptor present on macrophages. Whether this Spike/DPP4 association affects macrophage responses remains unknown. Herein we demonstrated that infection of macrophages with lentiviral particles pseudotyped with MERS-CoV S glycoprotein results in suppression of macrophage responses since it reduced the capacity of macrophages to produce TNFa and IL-6 in naive and LPS-activated THP-1 macrophages and augmented LPS-induced production of the immunosuppressive cytokine IL-10. MERS-CoV S glycoprotein induced the expression of the negative regulator of TLR signaling IRAK-M as well as of the transcriptional repressor PPARγ. Inhibition of DPP4 by its inhibitor sitagliptin or siRNA abrogated the effects of MERS-CoV S glycoprotein on IRAK-M, PPARγ and IL-10, confirming that its immunosuppressive effects were mediated by DPP4 receptor. The effect was observed both in THP-1 macrophages and human primary peripheral blood monocytes. These findings support a DPP4-mediated suppressive action of MERS-CoV in macrophages and suggest a potential target for effective elimination of its pathogenicity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kucharski, Aj" uniqKey="Kucharski A">AJ Kucharski</name></author><author><name sortKey="Althaus, Cl" uniqKey="Althaus C">CL Althaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Al Rabiah, Fa" uniqKey="Al Rabiah F">FA Al-Rabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al-Hajjar</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A Al-Barrak</name></author><author><name sortKey="Flemban, H" uniqKey="Flemban H">H Flemban</name></author><author><name sortKey="Al Nassir, Wn" uniqKey="Al Nassir W">WN Al-Nassir</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author><author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name></author><author><name sortKey="Makhdoom, Hq" uniqKey="Makhdoom H">HQ Makhdoom</name></author><author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Seilmaier, M" uniqKey="Seilmaier M">M Seilmaier</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Hartmann, W" uniqKey="Hartmann W">W Hartmann</name></author><author><name sortKey="Scheible, G" uniqKey="Scheible G">G Scheible</name></author><author><name sortKey="Sack, S" uniqKey="Sack S">S Sack</name></author><author><name sortKey="Guggemos, W" uniqKey="Guggemos W">W Guggemos</name></author><author><name sortKey="Kallies, R" uniqKey="Kallies R">R Kallies</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Junglen, S" uniqKey="Junglen S">S Junglen</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Haas, W" uniqKey="Haas W">W Haas</name></author><author><name sortKey="Guberina, H" uniqKey="Guberina H">H Guberina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author><author><name sortKey="Price, Cs" uniqKey="Price C">CS Price</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al Rabeeah</name></author><author><name sortKey="Cummings, Da" uniqKey="Cummings D">DA Cummings</name></author><author><name sortKey="Alabdullatif, Zn" uniqKey="Alabdullatif Z">ZN Alabdullatif</name></author><author><name sortKey="Assad, M" uniqKey="Assad M">M Assad</name></author><author><name sortKey="Almulhim, A" uniqKey="Almulhim A">A Almulhim</name></author><author><name sortKey="Makhdoom, H" uniqKey="Makhdoom H">H Makhdoom</name></author><author><name sortKey="Madani, H" uniqKey="Madani H">H Madani</name></author><author><name sortKey="Alhakeem, R" uniqKey="Alhakeem R">R Alhakeem</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name></author><author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name></author><author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name></author><author><name sortKey="Makhdoom, Hq" uniqKey="Makhdoom H">HQ Makhdoom</name></author><author><name sortKey="Palser, Al" uniqKey="Palser A">AL Palser</name></author><author><name sortKey="Ong, Sh" uniqKey="Ong S">SH Ong</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al Rabeeah</name></author><author><name sortKey="Alhakeem, Rf" uniqKey="Alhakeem R">RF Alhakeem</name></author><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Albarrak, A" uniqKey="Albarrak A">A Albarrak</name></author><author><name sortKey="Barry, M" uniqKey="Barry M">M Barry</name></author><author><name sortKey="Shibl, A" uniqKey="Shibl A">A Shibl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xia, S" uniqKey="Xia S">S Xia</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Sun, Z" uniqKey="Sun Z">Z Sun</name></author><author><name sortKey="Su, S" uniqKey="Su S">S Su</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, Ja" uniqKey="Demmers J">JA Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J Bao</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Van Kuppeveld, Fj" uniqKey="Van Kuppeveld F">FJ van Kuppeveld</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Qin, L" uniqKey="Qin L">L Qin</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Ye, S" uniqKey="Ye S">S Ye</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author><author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name></author><author><name sortKey="Wiersma, L" uniqKey="Wiersma L">L Wiersma</name></author><author><name sortKey="Ouwendijk, Wj" uniqKey="Ouwendijk W">WJ Ouwendijk</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Spronken, Mi" uniqKey="Spronken M">MI Spronken</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G van Amerongen</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, J" uniqKey="Zhong J">J Zhong</name></author><author><name sortKey="Rao, X" uniqKey="Rao X">X Rao</name></author><author><name sortKey="Deiuliis, J" uniqKey="Deiuliis J">J Deiuliis</name></author><author><name sortKey="Braunstein, Z" uniqKey="Braunstein Z">Z Braunstein</name></author><author><name sortKey="Narula, V" uniqKey="Narula V">V Narula</name></author><author><name sortKey="Hazey, J" uniqKey="Hazey J">J Hazey</name></author><author><name sortKey="Mikami, D" uniqKey="Mikami D">D Mikami</name></author><author><name sortKey="Needleman, B" uniqKey="Needleman B">B Needleman</name></author><author><name sortKey="Satoskar, Ar" uniqKey="Satoskar A">AR Satoskar</name></author><author><name sortKey="Rajagopalan, S" uniqKey="Rajagopalan S">S Rajagopalan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Arledge, Kc" uniqKey="Arledge K">KC Arledge</name></author><author><name sortKey="Chen, Yh" uniqKey="Chen Y">YH Chen</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Iy" uniqKey="Chen I">IY Chen</name></author><author><name sortKey="Chang, Sc" uniqKey="Chang S">SC Chang</name></author><author><name sortKey="Wu, Hy" uniqKey="Wu H">HY Wu</name></author><author><name sortKey="Yu, Tc" uniqKey="Yu T">TC Yu</name></author><author><name sortKey="Wei, Wc" uniqKey="Wei W">WC Wei</name></author><author><name sortKey="Lin, S" uniqKey="Lin S">S Lin</name></author><author><name sortKey="Chien, Cl" uniqKey="Chien C">CL Chien</name></author><author><name sortKey="Chang, Mf" uniqKey="Chang M">MF Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Wong, Bh" uniqKey="Wong B">BH Wong</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Cheng, Zs" uniqKey="Cheng Z">ZS Cheng</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Lee, Ac" uniqKey="Lee A">AC Lee</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name></author><author><name sortKey="Cai, Jp" uniqKey="Cai J">JP Cai</name></author><author><name sortKey="Chan, Ih" uniqKey="Chan I">IH Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F Song</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gierer, S" uniqKey="Gierer S">S Gierer</name></author><author><name sortKey="Bertram, S" uniqKey="Bertram S">S Bertram</name></author><author><name sortKey="Kaup, F" uniqKey="Kaup F">F Kaup</name></author><author><name sortKey="Wrensch, F" uniqKey="Wrensch F">F Wrensch</name></author><author><name sortKey="Heurich, A" uniqKey="Heurich A">A Heurich</name></author><author><name sortKey="Kramer Kuhl, A" uniqKey="Kramer Kuhl A">A Kramer-Kuhl</name></author><author><name sortKey="Welsch, K" uniqKey="Welsch K">K Welsch</name></author><author><name sortKey="Winkler, M" uniqKey="Winkler M">M Winkler</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Dittmer, U" uniqKey="Dittmer U">U Dittmer</name></author><author><name sortKey="Von Hahn, T" uniqKey="Von Hahn T">T von Hahn</name></author><author><name sortKey="Simmons, G" uniqKey="Simmons G">G Simmons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Zou, X" uniqKey="Zou X">X Zou</name></author><author><name sortKey="Hung, T" uniqKey="Hung T">T Hung</name></author><author><name sortKey="Lu, Z" uniqKey="Lu Z">Z Lu</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name></author><author><name sortKey="Kamat, V" uniqKey="Kamat V">V Kamat</name></author><author><name sortKey="Badithe, A" uniqKey="Badithe A">A Badithe</name></author><author><name sortKey="Fairhurst, J" uniqKey="Fairhurst J">J Fairhurst</name></author><author><name sortKey="Hunt, C" uniqKey="Hunt C">C Hunt</name></author><author><name sortKey="Strein, J" uniqKey="Strein J">J Strein</name></author><author><name sortKey="Berrebi, A" uniqKey="Berrebi A">A Berrebi</name></author><author><name sortKey="Sisk, Jm" uniqKey="Sisk J">JM Sisk</name></author><author><name sortKey="Matthews, Kl" uniqKey="Matthews K">KL Matthews</name></author><author><name sortKey="Babb, R" uniqKey="Babb R">R Babb</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Wong, Bh" uniqKey="Wong B">BH Wong</name></author><author><name sortKey="Cheng, Zs" uniqKey="Cheng Z">ZS Cheng</name></author><author><name sortKey="Poon, Vk" uniqKey="Poon V">VK Poon</name></author><author><name sortKey="Sun, T" uniqKey="Sun T">T Sun</name></author><author><name sortKey="Lau, Cc" uniqKey="Lau C">CC Lau</name></author><author><name sortKey="Wong, Kk" uniqKey="Wong K">KK Wong</name></author><author><name sortKey="Chan, Jy" uniqKey="Chan J">JY Chan</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wan, Z" uniqKey="Wan Z">Z Wan</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, D" uniqKey="Yu D">D Yu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Yoder, A" uniqKey="Yoder A">A Yoder</name></author><author><name sortKey="Spear, M" uniqKey="Spear M">M Spear</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tynell, J" uniqKey="Tynell J">J Tynell</name></author><author><name sortKey="Westenius, V" uniqKey="Westenius V">V Westenius</name></author><author><name sortKey="Ronkko, E" uniqKey="Ronkko E">E Ronkko</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="Melen, K" uniqKey="Melen K">K Melen</name></author><author><name sortKey="Osterlund, P" uniqKey="Osterlund P">P Osterlund</name></author><author><name sortKey="Julkunen, I" uniqKey="Julkunen I">I Julkunen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheuplein, Va" uniqKey="Scheuplein V">VA Scheuplein</name></author><author><name sortKey="Seifried, J" uniqKey="Seifried J">J Seifried</name></author><author><name sortKey="Malczyk, Ah" uniqKey="Malczyk A">AH Malczyk</name></author><author><name sortKey="Miller, L" uniqKey="Miller L">L Miller</name></author><author><name sortKey="Hocker, L" uniqKey="Hocker L">L Hocker</name></author><author><name sortKey="Vergara Alert, J" uniqKey="Vergara Alert J">J Vergara-Alert</name></author><author><name sortKey="Dolnik, O" uniqKey="Dolnik O">O Dolnik</name></author><author><name sortKey="Zielecki, F" uniqKey="Zielecki F">F Zielecki</name></author><author><name sortKey="Becker, B" uniqKey="Becker B">B Becker</name></author><author><name sortKey="Spreitzer, I" uniqKey="Spreitzer I">I Spreitzer</name></author><author><name sortKey="Konig, R" uniqKey="Konig R">R Konig</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Waibler, Z" uniqKey="Waibler Z">Z Waibler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Choi, Gk" uniqKey="Choi G">GK Choi</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name></author><author><name sortKey="Cai, Jp" uniqKey="Cai J">JP Cai</name></author><author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Che, Xy" uniqKey="Che X">XY Che</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, C" uniqKey="Schneider C">C Schneider</name></author><author><name sortKey="Nobs, Sp" uniqKey="Nobs S">SP Nobs</name></author><author><name sortKey="Heer, Ak" uniqKey="Heer A">AK Heer</name></author><author><name sortKey="Kurrer, M" uniqKey="Kurrer M">M Kurrer</name></author><author><name sortKey="Klinke, G" uniqKey="Klinke G">G Klinke</name></author><author><name sortKey="Van Rooijen, N" uniqKey="Van Rooijen N">N van Rooijen</name></author><author><name sortKey="Vogel, J" uniqKey="Vogel J">J Vogel</name></author><author><name sortKey="Kopf, M" uniqKey="Kopf M">M Kopf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gally, F" uniqKey="Gally F">F Gally</name></author><author><name sortKey="Kosmider, B" uniqKey="Kosmider B">B Kosmider</name></author><author><name sortKey="Weaver, Mr" uniqKey="Weaver M">MR Weaver</name></author><author><name sortKey="Pate, Km" uniqKey="Pate K">KM Pate</name></author><author><name sortKey="Hartshorn, Kl" uniqKey="Hartshorn K">KL Hartshorn</name></author><author><name sortKey="Oberley Deegan, Re" uniqKey="Oberley Deegan R">RE Oberley-Deegan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez Rodriguez, A" uniqKey="Fernandez Rodriguez A">A Fernandez-Rodriguez</name></author><author><name sortKey="Berenguer, J" uniqKey="Berenguer J">J Berenguer</name></author><author><name sortKey="Rallon, N" uniqKey="Rallon N">N Rallon</name></author><author><name sortKey="Jimenez Sousa, Ma" uniqKey="Jimenez Sousa M">MA Jimenez-Sousa</name></author><author><name sortKey="Lopez, Jc" uniqKey="Lopez J">JC Lopez</name></author><author><name sortKey="Soriano, V" uniqKey="Soriano V">V Soriano</name></author><author><name sortKey="Garcia Alvarez, M" uniqKey="Garcia Alvarez M">M Garcia-Alvarez</name></author><author><name sortKey="Cosin, J" uniqKey="Cosin J">J Cosin</name></author><author><name sortKey="Martinez, P" uniqKey="Martinez P">P Martinez</name></author><author><name sortKey="Guzman Fulgencio, M" uniqKey="Guzman Fulgencio M">M Guzman-Fulgencio</name></author><author><name sortKey="Miralles, P" uniqKey="Miralles P">P Miralles</name></author><author><name sortKey="Miguel Benito, J" uniqKey="Miguel Benito J">J Miguel Benito</name></author><author><name sortKey="Resino, S" uniqKey="Resino S">S Resino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zacharioudaki, V" uniqKey="Zacharioudaki V">V Zacharioudaki</name></author><author><name sortKey="Androulidaki, A" uniqKey="Androulidaki A">A Androulidaki</name></author><author><name sortKey="Arranz, A" uniqKey="Arranz A">A Arranz</name></author><author><name sortKey="Vrentzos, G" uniqKey="Vrentzos G">G Vrentzos</name></author><author><name sortKey="Margioris, An" uniqKey="Margioris A">AN Margioris</name></author><author><name sortKey="Tsatsanis, C" uniqKey="Tsatsanis C">C Tsatsanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Ha" uniqKey="Nguyen H">HA Nguyen</name></author><author><name sortKey="Rajaram, Mv" uniqKey="Rajaram M">MV Rajaram</name></author><author><name sortKey="Meyer, Da" uniqKey="Meyer D">DA Meyer</name></author><author><name sortKey="Schlesinger, Ls" uniqKey="Schlesinger L">LS Schlesinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez, E" uniqKey="Sanchez E">E Sanchez</name></author><author><name sortKey="Garcia Bermudez, M" uniqKey="Garcia Bermudez M">M Garcia-Bermudez</name></author><author><name sortKey="Jimenez Alonso, J" uniqKey="Jimenez Alonso J">J Jimenez-Alonso</name></author><author><name sortKey="De Ramon, E" uniqKey="De Ramon E">E de Ramon</name></author><author><name sortKey="Sanchez Roman, J" uniqKey="Sanchez Roman J">J Sanchez-Roman</name></author><author><name sortKey="Ortego Centeno, N" uniqKey="Ortego Centeno N">N Ortego-Centeno</name></author><author><name sortKey="Witte, T" uniqKey="Witte T">T Witte</name></author><author><name sortKey="D Lfonso, S" uniqKey="D Lfonso S">S D’Alfonso</name></author><author><name sortKey="Pons Estel, B" uniqKey="Pons Estel B">B Pons-Estel</name></author><author><name sortKey="Anders, Hj" uniqKey="Anders H">HJ Anders</name></author><author><name sortKey="Alarcon Riquelme, Me" uniqKey="Alarcon Riquelme M">ME Alarcon-Riquelme</name></author><author><name sortKey="Martin, J" uniqKey="Martin J">J Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyroni, K" uniqKey="Lyroni K">K Lyroni</name></author><author><name sortKey="Patsalos, A" uniqKey="Patsalos A">A Patsalos</name></author><author><name sortKey="Daskalaki, Mg" uniqKey="Daskalaki M">MG Daskalaki</name></author><author><name sortKey="Doxaki, C" uniqKey="Doxaki C">C Doxaki</name></author><author><name sortKey="Soennichsen, B" uniqKey="Soennichsen B">B Soennichsen</name></author><author><name sortKey="Helms, M" uniqKey="Helms M">M Helms</name></author><author><name sortKey="Liapis, I" uniqKey="Liapis I">I Liapis</name></author><author><name sortKey="Zacharioudaki, V" uniqKey="Zacharioudaki V">V Zacharioudaki</name></author><author><name sortKey="Kampranis, Sc" uniqKey="Kampranis S">SC Kampranis</name></author><author><name sortKey="Tsatsanis, C" uniqKey="Tsatsanis C">C Tsatsanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, Ck" uniqKey="Glass C">CK Glass</name></author><author><name sortKey="Saijo, K" uniqKey="Saijo K">K Saijo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vergadi, E" uniqKey="Vergadi E">E Vergadi</name></author><author><name sortKey="Vaporidi, K" uniqKey="Vaporidi K">K Vaporidi</name></author><author><name sortKey="Theodorakis, Ee" uniqKey="Theodorakis E">EE Theodorakis</name></author><author><name sortKey="Doxaki, C" uniqKey="Doxaki C">C Doxaki</name></author><author><name sortKey="Lagoudaki, E" uniqKey="Lagoudaki E">E Lagoudaki</name></author><author><name sortKey="Ieronymaki, E" uniqKey="Ieronymaki E">E Ieronymaki</name></author><author><name sortKey="Alexaki, Vi" uniqKey="Alexaki V">VI Alexaki</name></author><author><name sortKey="Helms, M" uniqKey="Helms M">M Helms</name></author><author><name sortKey="Kondili, E" uniqKey="Kondili E">E Kondili</name></author><author><name sortKey="Soennichsen, B" uniqKey="Soennichsen B">B Soennichsen</name></author><author><name sortKey="Stathopoulos, En" uniqKey="Stathopoulos E">EN Stathopoulos</name></author><author><name sortKey="Margioris, An" uniqKey="Margioris A">AN Margioris</name></author><author><name sortKey="Georgopoulos, D" uniqKey="Georgopoulos D">D Georgopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arranz, A" uniqKey="Arranz A">A Arranz</name></author><author><name sortKey="Androulidaki, A" uniqKey="Androulidaki A">A Androulidaki</name></author><author><name sortKey="Zacharioudaki, V" uniqKey="Zacharioudaki V">V Zacharioudaki</name></author><author><name sortKey="Martinez, C" uniqKey="Martinez C">C Martinez</name></author><author><name sortKey="Margioris, An" uniqKey="Margioris A">AN Margioris</name></author><author><name sortKey="Gomariz, Rp" uniqKey="Gomariz R">RP Gomariz</name></author><author><name sortKey="Tsatsanis, C" uniqKey="Tsatsanis C">C Tsatsanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doxaki, C" uniqKey="Doxaki C">C Doxaki</name></author><author><name sortKey="Kampranis, Sc" uniqKey="Kampranis S">SC Kampranis</name></author><author><name sortKey="Eliopoulos, Ag" uniqKey="Eliopoulos A">AG Eliopoulos</name></author><author><name sortKey="Spilianakis, C" uniqKey="Spilianakis C">C Spilianakis</name></author><author><name sortKey="Tsatsanis, C" uniqKey="Tsatsanis C">C Tsatsanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Grèce</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Al Qahtani, Ahmed A" sort="Al Qahtani, Ahmed A" uniqKey="Al Qahtani A" first="Ahmed A." last="Al-Qahtani">Ahmed A. Al-Qahtani</name></noRegion><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N." last="Al-Ahdal">Mohammed N. Al-Ahdal</name><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N." last="Al-Ahdal">Mohammed N. Al-Ahdal</name><name sortKey="Al Anazi, Mashael R" sort="Al Anazi, Mashael R" uniqKey="Al Anazi M" first="Mashael R." last="Al-Anazi">Mashael R. Al-Anazi</name><name sortKey="Al Qahtani, Ahmed A" sort="Al Qahtani, Ahmed A" uniqKey="Al Qahtani A" first="Ahmed A." last="Al-Qahtani">Ahmed A. Al-Qahtani</name><name sortKey="Alkahtani, Saad" sort="Alkahtani, Saad" uniqKey="Alkahtani S" first="Saad" last="Alkahtani">Saad Alkahtani</name></country><country name="Grèce"><noRegion><name sortKey="Lyroni, Konstantina" sort="Lyroni, Konstantina" uniqKey="Lyroni K" first="Konstantina" last="Lyroni">Konstantina Lyroni</name></noRegion><name sortKey="Aznaourova, Marina" sort="Aznaourova, Marina" uniqKey="Aznaourova M" first="Marina" last="Aznaourova">Marina Aznaourova</name><name sortKey="Sourvinos, George" sort="Sourvinos, George" uniqKey="Sourvinos G" first="George" last="Sourvinos">George Sourvinos</name><name sortKey="Tsatsanis, Christos" sort="Tsatsanis, Christos" uniqKey="Tsatsanis C" first="Christos" last="Tsatsanis">Christos Tsatsanis</name><name sortKey="Tseliou, Melpomeni" sort="Tseliou, Melpomeni" uniqKey="Tseliou M" first="Melpomeni" last="Tseliou">Melpomeni Tseliou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000776 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000776 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5354714
|texte= Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28118607" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |